Zepbound (tirzepatide) works through a unique dual-action approach that targets both GLP-1 and GIP receptors in your body. This combination helps regulate appetite signals in your brain, slows down digestion so you feel fuller longer, and improves how your body processes sugar and fat. Unlike older weight management medications that focused on one mechanism, Zepbound's dual-receptor approach creates a more comprehensive effect on your body's metabolic systems.

The key difference is Zepbound's dual-receptor activation technology. While medications like Wegovy and Ozempic only target the GLP-1 receptor, Zepbound engages both GLP-1 and GIP receptors. This dual approach has shown to potentially deliver greater weight reduction in clinical trials—up to 20% body weight loss in one year for some patients, compared to approximately 15% with single-receptor medications. Additionally, Zepbound is available in both vials and pens, offering more flexibility in administration options.

Most patients begin with a lower dose (2.5mg weekly) that gradually increases based on your body's response and tolerance. During the first few weeks, you may experience side effects as your body adjusts to the medication—these typically include nausea, digestive changes, and sometimes fatigue. These effects generally improve as your body adapts. Most patients begin noticing changes in appetite within the first two weeks, while measurable weight changes typically appear within 4-8 weeks of consistent use.

Zepbound can be used with many medications, but there are important interactions to consider. It may affect how quickly your body absorbs oral medications (including certain antibiotics and birth control pills) due to its effect on digestion speed. If you're taking oral contraceptives, additional contraception methods may be recommended during adjustment periods. Blood pressure and diabetes medications might require dosage adjustments as Zepbound begins working. Always provide your provider with a complete list of all medications and supplements you're taking.

If you discontinue Zepbound, your body will gradually return to its previous appetite regulation patterns. Some weight regain is common after stopping treatment, but this varies significantly between individuals. For long-term success, we recommend developing sustainable lifestyle modifications during treatment that can continue afterward. If you need to pause treatment temporarily (for surgery, pregnancy planning, etc.), your DevotedMD provider will create a personalized plan for safely tapering and potentially resuming treatment when appropriate.